Low-Grade Lymphomas

Treatment approaches to the low-grade lymphomas.

Somatic hypermutation signature in B-cell low-grade lymphomas.

BACKGROUND Immunoglobulin gene somatic hypermutation is a biologically relevant and clinically useful prognostic factor in different types of low-grade B-cell lymphomas, including chronic lymphocytic leukemia, mantle cell lymphoma and splenic marginal zone lymphoma. DESIGN AND METHODS With the aim of identifying surrogate markers of somatic hypermutation, a combined investigation of IgV(H) mu...

Algorithm for immunophenotyping of low-grade B lymphomas.

In September 1994, Harris et al' published their Proposal for a Revised European-American Classification of Lymphoid Neoplasms. We have found their report extremely useful for practical work and consider i t a great step forward in the understanding of the biologic behavior of lymphomas for the following reasons. (1) They postulated the presumed normal counterpm of the lymphoma cell and also de...

Cytogenetic findings in peripheral T-cell lymphomas as a basis for distinguishing low-grade and high-grade lymphomas.

Cytogenetic studies on lymph node and skin biopsy specimens and peripheral blood in 104 patients with peripheral T-cell lymphomas (PTL) were compared with histopathologic diagnoses made according to the updated Kiel classification. Low-grade lymphomas presented normal metaphases more frequently than high-grade ones (P < .0001). This difference remained significant if cases with greater than 10%...

The role of surgery in the treatment of gastrointestinal lymphomas other than low-grade MALT lymphomas.

BACKGROUND AND OBJECTIVE A bias in clinical investigations on gastrointestinal lymphomas is the lack of testing the intention to treat as to resection, emergency conditions at presentation and selection brought about by the evaluation of feasibility of surgery. DESIGN AND METHODS A prospective study involved 154 patients with gastrointestinal nodular or high-grade MALT lymphomas, 111 with a g...